Experts talks In vitro liver models for reliable predictions in preclinical stages

Experts talks: In vitro liver models for reliable predictions in preclinical stages

Experts talks: In vitro liver models for reliable predictions in preclinical stages

The advent of new alternative methodologies marks a significant stride forward in biomedical research, enabling safer and more ethical testing by reducing reliance on animal studies. 

The current trend in preclinical research is developing in vitro models that reliably recreate the cellular microenvironment to mimic in vivo behavior closely. Easy access to primary cells is crucial to developing them.  

In this interview, we chatted with Natalia Sánchez, Research and Development Director at BeCytes, about the importance of in vitro liver models and BeCytes’ cell procurement service in developing them. BeCytes Biotechnologies offers a broad portfolio of primary human liver cells that can help you recreate the hepatic microenvironment in vitro.

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Why is it crucial to develop reliable in vitro liver models?

There are two main reasons. The first one is that in vitro models provide a more accurate platform to study liver diseases, their physiology, and pharmacokinetics in a general way, allowing a more direct interpretation of how a drug or therapy might behave in the human body. It is essential for predicting efficacy and safety before clinical trials, thus optimizing resources and reducing the risks associated with early-stage drug development.

The second reason is directly related to research. Models that recreate the liver microenvironment enable deeper investigations into specific liver diseases’ mechanisms and responses to new treatments. These advanced models incorporate the cellular complexity and architecture of the human liver. They offer a more dynamic and realistic context for experimentation.

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How can BeCytes help researchers develop liver in vitro models?

At BeCytes, we are at the forefront of aiding researchers in crafting sophisticated liver in vitro models. Our expertise lies in the precise isolation and comprehensive characterization of cells for groundbreaking research. Offering both fresh and cryopreserved primary liver cells — including hepatocytes, Kupffer Cells, Liver Sinusoidal Endothelial Cells, Stellate Cells, and mixed non-parenchymal cells — our unique capability to isolate all these cell types from a single donor sets us apart. 

This approach ensures a more accurate recreation of the liver’s physiological microenvironment in vitro. Our cells, sourced from healthy and diseased donors, maintain essential characteristics of in vivo liver cells, enabling the development of highly accurate in vitro models. With our specialized knowledge and skills, BeCytes is a crucial support pillar for researchers tackling complex challenges in liver model development.

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How can we be sure that BeCytes’ cells retain a stable phenotype?

All our cell services come with a certificate of analysis that includes donor demographics, cell number, viability after thawing, and morphological analysis. Additionally, we ensure that our cells are further characterized with specific assays such as metabolism, induction, immunofluorescence, and flow cytometry to guarantee the expression of specific markers.

Our inventory is always available online to find the perfect lot for your needs, and we provide info about the passage, the donor, the lot, and the stock.

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What are the advantages n we be sure that BeCytes’ cells retain a stable phenotype?

At BeCytes, our deep expertise in cell isolation and characterization is a key competitive advantage we offer researchers. We excel in providing diverse cell types from a single donor liver, enabling our in vitro models to mirror the human liver’s physiological environment more accurately. This approach results in more authentic and translational research outcomes.

We view our service as a collaborative partnership, always ready to adapt our offerings to meet the unique needs of our clients, including exploring new cellular experiments. Partnering with BeCytes means accessing tailored solutions that enhance the fidelity and relevance of your research.

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How is high fidelity translated into fundamental discoveries?

This fidelity is indispensable for bridging the bench and bedside gap. The more reliable the model, the more reliable the results obtained in the preclinical phase of the drug discovery and development process. This advances scientific understanding and accelerates the development of therapies that can transform lives. 

Do you have any more questions about our cell procuring service? 

Don’t hesitate to contact us!

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