The most accurate representation of in vivo cellular function and characteristics can be achieved with plateable hepatocytes. BeCytes Biotechnologies cryopreserved human plateable hepatocytes are qualified by their ability to maintain a confluent monolayer (85% confluency) for at least five days. Plateable hepatocytes cells can also be used for suspension studies.
BeCytes Biotechnologies Plateable hepatocytes cells are Cryopreserved primary human hepatocytes (HuHEC). HuHEC are human liver cells that have been isolated from healthy and pathological donor livers and preserved by cryopreservation techniques for later use in research allowing researchers to organize experiments at their convenience.
HuHEC retain important characteristics of liver cells found in the human body, and they serve as valuable tools for a wide range of research applications.
| Ref. | Product |
|---|---|
| HuHECP | Plateable |
| HuHECP-30 | Plateable & 3D Certified |
| HuHECPMI | Plateable - Metabolism & Induction Certified |
| HuHECPMI-3D | Plateable – Metabolism, Induction Certified & 3D Qualified |
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- 3D/Spheroid Qualified: Lot tested positively for 3D culture (Spheroids)
- 24/96 Well Qualified: Plateable in 24/96 well plate
- Days in culture 24w: Keep monolayer and good morphology in 24 well plate under proper condition
Plateable hepatocytes are characterized by their ability to adhere and form a confluent monolayer on culture dishes or plates coated with extracellular matrix proteins like collagen. This adherence property makes them particularly valuable when researchers need a well-differentiated hepatocyte model to study long-term liver functions. They are often employed in assays related to drug metabolism, toxicity testing, and liver-specific disease modeling.
These hepatocytes (Plateable Hepatocytes) are considered the preferred choice for determining the metabolic stability and metabolism of new compounds in development
Primary Plateable Hepatocytes Characterization
Basic Characterization
- Cell number and viability after thawing
- Optimal seeding density (24 and 96-well plate)
- Adhesion capacity
- Morphology of the cells in culture
- Ability to generate spheroids
- Number of days the cells are in culture
Advanced Characterization
- Induction assays testing the ability of cytochromes to overexpress.
- Metabolisation assays in which the resulting metabolites shall be detected and quantified.
- WGS genotyping from our lots included.
Common Uses
- Metabolism analysis
- Toxicity assessments
- Enzyme activity studies
- Prediction of metabolic clearance
- Drug-drug interaction assays
- Hepatotoxicity
- Among Others
BeCytes Biotechnologies Primary Plateable Hepatocytes are produced under rigorous QC Standards and supplied with:
- Demographic and clinical donor profile
- Hepatocyte characterization
- Specific COA with culture and maintenance protocols
- Specific hepatocytes media
Features and Benefits
BeCytes Biotechnologies’ primary human plateable hepatocytes are isolated from single donors and processed the same day to ensure their best performance.
Shipping
We avoid shipments arriving on weekends or holidays.
We store and ship all cell products at the most favorable temperature range for the product and we monitor the safety and integrity of shipped products proactively.
All of our products are delivered in compliance of the IATA Dangerous Goods Regulations.
Shipping conditions: Dry ice (-80ºC)/ LN (-196ºC)
Packaging
Packaging and shipping fresh products to preserve its quality when transporting, to ensure that all primary cell products are protected with integrity and viability.
Leak-proof packaging materials that meet the general requirements of carriers and customs authorities, where applicable usually ship at room temperature.
Obtain Personalized Advice from BeCytes Scientific and Sales Experts
At BeCytes Biotechnologies, we will personally advise you to obtain the liver cells that best suit the conditions of your project.
From the moment you contact us, our experts will follow the following steps
- Detailed study of the requirements described on the form
- Personalized advice according to the needs of each client
- Permanent contact throughout the process to ensure the best results
Fill in the following form and we will contact you with an answer to your request.
