Primary Human Hepatic Stellate Cells
Human Hepatic stellate cells (HSCs) are liver-specific mesenchymal cells and are located in the space of Disse, between endothelial cells of the sinusoid and hepatocytes. These cells are the major cell type involved in liver fibrosis in response to liver injury, and they play a key role in the homeostasis of liver extracellular matrix, repair, regeneration and fibrosis, and control retinol metabolism, storage and release.
In their quiescent state, Human Hepatic stellate cells contain numerous vitamin A lipid droplets, constituting the largest reservoir of vitamin A in the body. Besides, Human Hepatic stellate cells has the capability to change into their activated stage transdifferentiating into myofibroblast-likecells which are linked with the pathogenesis of hepatic fibrosis.
| Ref. | Product | Packaging |
|---|---|---|
| HuSC-P1 | Stellate cells, passage 1 | 100.000 500.000 |
| HuSC-P2 | Stellate cells, passage 2 | 100.000 500.000 |
| HuSC-P3 | Stellate cells, passage 3 | 100.000 500.000 |
| HuSCP | Plated Stellate cells | 1 plate |
Human Hepatic stellate cells has the capability to change into their activated stage transdifferentiating into myofibroblast-like cells which are linked with the pathogenesis of hepatic fibrosis.
Moreover, activated Stellate cells can proliferate, contract, and regulate chemotaxis becoming the main source of
extracellular matrix production during liver injury. This leads to the secretion of collagen which provides a scaffold for hepatocytes to repopulate during tissue regeneration and can lead to cirrhosis.
Human Hepatic stellate cells Charaterization
- Charaterization I
- Cell number and viability after thawing
Morphological analysis of cells over time
- Cell number and viability after thawing
- Charaterization II
Cytes Biotechnology uses key antibodies by immunofluorescence to characterize stellate cells showing their expression at the quiescent and activated state of the cells.
Common Uses
Cell Based Assays
- Toxicity
- Drug screening
- Metabolism
Useful tool to study
- Liver function
- Physiology
- Liver diseases (Fibrotic Models)
Human Hepatic Stellate cells are produced under rigorous QC standards and supplied with:
- Demographic and clinical donor profile
- Viability and morphology assessment
- Specific COA with culture and maintenance protocols
- Specific Human Hepatic Stellate cells media
Shipping
We avoid shipments arriving at weekends or holidays.
We store and ship all cell products at the most favorable temperature range for the product and we monitor the safety and integrity of shipped products proactively.
All of our products are delivered in compliance of the IATA Dangerous Goods Regulations.
Shipping conditions: Dry ice (-80ºC)/ LN (-196ºC)
Packaging
Packaging and shipping fresh products to preserve its quality when transporting, to ensure that all primary cell products are protected with integrity and viability.
Leak-proof packaging materials that meet the general requirements of carriers and customs authorities, where applicable usually ship at room temperature.
Obtain personalized advice from Cytes Scientific and Sales experts
At Cytes Biotechnologies we will personally advise you to obtain the liver cells that best suit the conditions of your project.
From the moment you contact us, our experts will follow the following steps
- Detailed study of the requirements described on the form
- Personalized advice according to the needs of each client
- Permanent contact throughout the process to ensure the best results
Fill in the following form and we will contact you with an answer to your request.
