Primary Human NPCs Mix

Human Non-Parenchymal cells Mix (Human NPCs Mix) constitutes about 30% of the total liver cell population and are specialized cells which interact with hepatocytes for physiological liver functions.
NPCs present organotypic hepatocytes – Non-Parechymal cells interactions via direct contact or paracrine signaling, and forming a functional hepatic unit.
Among their many functions, Non-Parenchymal cells play an important role for liver regeneration as well as recovery from inflammatory liver injury and scaring.
Ref. Product
HuNPC  Mix Non-Parenchymal cells (NPC)
HuNPC+  Mix Non-Parenchymal cells (NPC) with additional characterization information
NPCs MIX STOCK  ​
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Because liver function relies on so much more than hepatocytes themselves, co-cultures with Non-Parenchymal Cells are critical for every in vitro liver model. For this reason, liver co-cultures may increase the sensitivity of liver models for ADME/Tox-related research by recapitulating the complexity of a whole liver.
“NPCs Mix” provides a mix of different types of liver cells, including Kupffer cells, liver endothelial and liver endothelial sinusodial cells and Stellate cells.

 

Primary Human NPCs Mix Charaterization

Basic Characterization

  • Determination of cell number and viability.
  • Determination of viability over time (t=5h).

Additional Characterization

The principal markers present in the NPC cell fraction are used to determine their expression and percentage.

Common Uses

  • Inflammation and immune response studies
  • Fibrosis and cirrhosis research
  • Drug metabolism and toxicity screening
  • Liver regeneration studies
  • Viral infection models
  • Metabolic and lipid research
  • Cell signaling and gene expression studies

Advanced liver models, including those with in vivo-like environments and liver co-cultures, are essential for accurate predictive responses in studying liver physiology/pathology and conducting drug screenings, offering increased sensitivity and the ability to manipulate various conditions and analyze multiple parameters. Human “Mix NPCs” provide a mixture of different types of liver cells.

Human NPCs Mix are produced under rigorous QC Standards and supplied with:

  • Demographic and clinical donor profile
  • Viability and morphology assessment
  • Specific COA with culture and maintenance protocols
  • Specific NPCs thawing media

Shipping

We avoid shipments arriving at weekends or holidays.
We store and ship all cell products at the most favorable temperature range for the product, and we monitor the safety and integrity of shipped products proactively.
All of our products are delivered in compliance of the IATA Dangerous Goods Regulations.
Packaging

Packaging and shipping fresh products to preserve its quality when transporting, to ensure that all primary cell products are protected with integrity and viability.
Leak-proof packaging materials that meet the general requirements of carriers and customs authorities, where applicable usually ship at room temperature.

Related Products

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Primary Kupffer Cells

Primary Human Hepatic Stellate Cells

liver endothelial cells

Human Liver Endothelial Cells

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