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How to culture liver organoids  Organoids are three-dimensional (3D) structures derived from stem cells, progenitors, or differentiated cells that self-organize to recapitulate aspects of the native tissue architecture and [...]

What non-parenchymal cell types are present in the liver?  Non-parenchymal cells (NPCs) are the diverse cell types found in the liver that are not hepatocytes. These cells make up [...]

The drug discovery and development process has a bottleneck: the use of animal models in preclinical stages. Animal use is costly, time-consuming, and implies ethical concerns.  Governments and regulatory [...]

. Contract Research Organizations (CROs) are much more than mere companies that offer support to the pharmaceutical or biotechnology industries in the form of research services outsourced on a [...]

. New Alternative Models (NAMs) for research, which include in vitro cellular models, are destined to transform the future of biomedical research. Regulatory agencies implement laws concerning animal use [...]

Metabolic (dysfunction) associated fatty liver disease (MAFLD) is the most common chronic liver disease, affecting around 25 % of the world population. It is characterized by an accumulation of [...]