In vitro models for MAFLD: a 2024 update
Metabolic (dysfunction) associated fatty liver disease (MAFLD) is the most common chronic liver disease, affecting around 25 % of the world population. It is characterized by an accumulation of [...]
Bioprinted in vitro liver models to propel clinical advances in drug development
Liver models to test new drugs based on 2D cell culture of primary hepatocytes and the use of experimental animal models are slow, costly, and have significant biases. BeCytes [...]
Predict Drug-Induced Liver Injury (DILI) with Primary Human Hepatocyte Spheroids
Drug-induced liver injury (DILI) has fatal consequences, both personally and economically. Its health impact ranges from mild liver enzyme elevation to severe liver failure. In the drug development process, [...]
3D liver models for drug testing
Regulatory agencies, such as the Food and Drug Administration (FDA), are moving towards reducing animal testing and encouraging the use of New Alternative Methodologies (NAMs) in pharmaceutical research. NAMs [...]
Experts talks: In vitro liver models for reliable predictions in preclinical stages
Experts talks: In vitro liver models for reliable predictions in preclinical stages The advent of new alternative methodologies marks a significant stride forward in biomedical research, enabling safer and [...]
Organoids vs Spheroids: 3 important differences
Organoids vs Spheroids: 3 important differences The evolution from 2D monolayer cultures towards 3D cell cultures has marked a crucial advance for modeling human development and diseases. Since the [...]
